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Diag’nCell services are based on a broad range of cutting edge skills dedicated to the precise evaluation of functional biological properties.
Human induced pluripotent stem cells
Heterologous expression systems (HEK/CHO...)
Zebrafish
Drosophila
Nematod (C. Elegans)
Ion channel biophysical characterization: control/pathological variations (with or without treatment).
Differentiation of cardiomyocytes from hiPSC (hiPSC-CM).
Evaluation of hiPSC-CM contractile properties.
Study of genetic variations (not affecting gene coding for an ion channel).
Electrophysiological characterization of hiPSC-CM.
Study of gene expression levels.
Design and development of a hiPSC line.
Study of cardiac calcium dynamics (cellular and molecular level).