MODELS AND TECHNOLOGIES

Diag’nCell services are based on a broad range of cutting edge skills dedicated to the precise evaluation of functional biological properties.

MODELS

Human induced pluripotent stem cells

Heterologous expression systems (HEK/CHO...)

Zebrafish

Drosophila

Nematod (C. Elegans)

Ion channel biophysical characterization: control/pathological variations (with or without treatment).

Differentiation of cardiomyocytes from hiPSC (hiPSC-CM).

Evaluation of hiPSC-CM contractile properties.

Study of genetic variations (not affecting gene coding for an ion channel).

Electrophysiological characterization of hiPSC-CM.

Study of gene expression levels.

Design and development of a hiPSC line.

Study of cardiac calcium dynamics (cellular and molecular level).