ADDRESSES

Headquarters

Pépinière Laënnec - Bioparc

60 Avenue Rockefeller

69008 LYON

FRANCE

Laboratories

Bâtiment IURC Institut Universitaire de Recherche Clinique
641 Avenue du Doyen Gaston Giraud

34090 MONTPELLIER

FRANCE

DIAG'NCELL

SIREN : 849 573 274 R.C.S. Lyon

DRUG RATIONALIZATION

CONTEXT

Genetic tests have become routinely used as a support in the patient diagnostic pathway. Nevertheless, the association between genetic knowledge and the most appropriate medicine for a given patient remains to be strengthened.

WHY ?

When multiple drugs are available to clinicians, we use biological models expressing genetic variations found in patients to evaluate drug response in a patient-specific environment. Drugs are classified according to their relevance in normalizing defects associated with the variation.

MODELS

Patient-specific genetic variations are expressed in the most relevant biological models:

  • Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM)

  • Heterologous expression systems (HEK, CHO cells...)

  • Zebrafish

  • Drosophila

  • Nematod (C. Elegans)

TECHNOLOGIES

Biological models are used in combination with the most accurate approaches, including:

  • Electrophysiology (manual and automated path-clamp)

  • Fluorescence microscopy (conventional and confocal)

  • Calcium dynamics recording

  • In-vivo heart function evaluation (Zebrafish)